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Here's a video showing how I got 460,000 score on insane difficulty. The general idea is to use Waterfall (water/nature) towers to boost your strong towers' DPS by 90% You eventually get Invocation (nature/light/earth) towers to amplify damage further. Percentage increases in amplification or buffs are very strong when you have a few very strong towers. You will end up with 3 pure element towers that can deal a lot of damage.