I have several times tried to create the best combo. I have tried getting 3 3 3111, 2-2-2-1-2-2 etc.
My best comes from 222-111 and two mangoes. It is most important that you get the final tower and as many as you can.
Second advice is to build slow tower to accommodate their damage. It is hard because then i get to little damage and lose lives before i get super tower but in my best estimate i had 10 lives by the time i for my first super tower at 40 or 45 and made it to lvl 7 frogs.