Hello.
I'm not sure if it's something fixable, or if it's an issue how dota handles mods.
But in short, I usually bind my space to another function (centering camera on hero), but after playing ETD the bind will be used for toggling the tree, but once I am done the bind isn't set back to what it was before my ETD game.
Not a huge issue, but annoying when I go back to normal games.